New ENU Mouse Models for Neuroscience Research

As part of a trans-NIH initiative to increase genomic and genetic resources, three centers for chemical mutagenesis and neurobiological and behavioral phenotypic screening were established. The purpose of these centers is to create new mouse models for neuroscience research ( The new mutant mouse lines should be important tools for functional gene identification as well as providing new and unique altered phenotypes for physiological and behavioral research.

All mouse lines produced from all three sites (the Neurogenomics Project at Northwestern University, Joseph S. Takahashi, P.I.; the Neuroscience Mutagenesis Facility at the Jackson Laboratory, Wayne N. Frankel, P.I.; and the Neuromutagenesis Project of the Tennessee Mouse Genome Consortium, Daniel Goldowitz, P.I.) are available to interested scientists. To facilitate making information about the new mouse lines available, as well as to facilitate their distribution, a searchable database of neuroscience-relevant mutant mouse lines is now available at

The database includes both genetic and phenotypic information about the mice. A variety of search and sort tools are available to browse through the mouse lines. By registering with the site, search results can be saved for later use, and users can request automatic searches at a chosen time interval with the results to be emailed to them. In addition, information on the phenotypic screens used to identify the mutants is available, and ordering mice from any of the three centers is possible.

This resource is supported by the National Institute of Mental Health, the National Institute of Neurological Disorders and Stroke, the National Institute on Aging, the National Institute on Deafness and Other Communication Disorders, the National Institute on Drug Abuse, the National Eye Institute, and the National Institute on Alcohol Abuse and Alcoholism.